Inflammation, Coagulation, and the Pathway to Frailty
نویسندگان
چکیده
منابع مشابه
Contact pathway of coagulation and inflammation
The contact system, also named as plasma kallikrein-kinin system, consists of three serine proteinases: coagulation factors XII (FXII) and XI (FXI), and plasma prekallikrein (PK), and the nonenzymatic cofactor high molecular weight kininogen (HK). This system has been investigated actively for more than 50 years. The components of this system and their interactions have been elucidated from in ...
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Severe infection and inflammation almost invariably lead to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation (DIC). Systemic inflammation results in activation of coagulation, due to tissue factor-mediated thrombin generation, downregulation of physiological anticoagulant mechanisms, and inhibition of fibrinolysis. Pro-infl...
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ژورنال
عنوان ژورنال: The American Journal of Medicine
سال: 2009
ISSN: 0002-9343
DOI: 10.1016/j.amjmed.2009.01.030